The Buffalo Bills don’t have to worry about containing running back Joe Mixon or defensive end Jerry Hughes in their Week 5 clash with the Houston Texans, as the AFC South club has ruled both players out for this Sunday’s matchup on their final injury report of the week.

The Bills will look to bounce back after a losing effort against the Baltimore Ravens in Week 5, while the Texans (3-1) hope to further prove they belong at the top of the AFC. The Bills (3-1) are favored by just one point. The Texans will be a tough test for a Bills team that is decimated by injury on defense.