The 49ers (2-3) blew a 10-point, fourth-quarter lead and fell 24-23 to the visiting Arizona Cardinals in record heat at ...

San Francisco 49ers wide receiver Brandon Aiyuk finally broke out in a 24-23 home loss to the Arizona Cardinals on Sunday.

An Aiyuk trade ultimately never came to fruition not only for the Steelers, but for any interested team. The wideout wound up ...

After a series of sluggish performances since becoming one of the NFL's highest-paid wide receivers, Brandon Aiyuk played like a man intent on silencing ...

The 49ers are 2-3 after losing to the Cardinals at home, and now they have to turn around and play the Seahawks in Seattle on ...

Watch San Francisco 49ers wide receiver Brandon Aiyuk's Week 5 highlights from his 147-yard game against the Arizona Cardinals.

Watch San Francisco 49ers wide receiver Brandon Aiyuk's best catches from 147-yard game in the Week 5 matchup against the ...

San Francisco 49ers wide receiver Brandon Aiyuk's eighth catch vs. Arizona Cards gets SF down to ARI 21-yard line in the fourth quarter.

The 30-year-old Kittle carries a 23-225-3 receiving line through four games ahead of a crucial matchup between NFC West contenders when the 49ers visit the Seahawks on Thursday.

San Francisco 49ers RB Jordan Mason found a gap and rushed for 34 yards on this play vs. the Arizona Cardinals.

San Francisco 49ers quarterback Brock Purdy's 53-yard connection with wide receiver Brandon Aiyuk comes on the 49ers' first ...

San Francisco 49ers wide receiver Brandon Aiyuk crosses the 100-yard mark on just his fifth catch vs. Arizona Cardinals.