San Francisco veteran kicker Jake Moody suffered a high right ankle sprain while attempting to make a tackle on a kick return ...

The Arizona Cardinals tried their hardest to beat themselves against San Francisco in the first half, but a tale of two halves showed strong positive developmen ...

The defense wilted in the heat, the offense couldn’t finish drives or protect the ball and the San Francisco 49ers blew ...

Here’s what fans and analysts were saying on Twitter after the 49ers dropped a shocking loss to the Cardinals in Week 5.

Brock Purdy had two costly interceptions against the Cardinals, resulting in a disappointing one-point loss for the 49ers.

Another week, another full slate of NFL action nearly in the books. And Week 5 has had no shortage of drama up to this point, ...

The 49ers are 2-3 after losing to the Cardinals at home, and now they have to turn around and play the Seahawks in Seattle on ...

Watch San Francisco 49ers quarterback Brock Purdy's best plays vs. the Arizona Cardinals in the Week 5 matchup.

Postgame, both Murray and Brock Purdy had a brief interaction following a hard-fought matchup. The two young quarterbacks, ...

The San Francisco 49ers were thought to be among the favorites to represent the NFC in the Super Bowl for a second straight year, but they haven't ...

NFL legend Tom Brady recalled facing San Francisco 49ers quarterback Brock Purdy during his first career start in Week 14 of ...

SANTA CLARA, Calif. (AP) — Kyler Murray had a long touchdown run in the first quarter and rallied Arizona with two ...