Seahawks vs. 49ers odds, prediction, time, spread: Thursday Night Football picks from NFL model on 45-23 roll
Kickoff from Lumen Field in Seattle is set for 8:15 p.m. ET. The 49ers are 3.5-point favorites in the latest Seahawks vs. 49ers odds via SportsLine Consensus, while the over/under for total points scored is 49. Before making any 49ers vs. Seahawks picks, be sure to see the NFL predictions and betting advice from SportsLine's proven computer model.